PART V: MEDIA (in chronological order)
- This study highlights the benefits of a critical growth factor for cultured meat production.
- This paper shows that adding heme proteins makes cultured meat tastier and faster to grow.
- Ever wondered why we need better culture media? This paper explains it all!
- This paper was the foundation for New Harvest Research Fellow Zachary’s 2021 publication on culture media optimization (the paper #5 below).
- Optimizing media is critical to scale. Machine learning makes the tedious experiments to optimize culture media faster and more efficient.
- This paper looks at further improving upon the machine learning approach to media optimization published in 2021 (the paper #5 above).
- This paper shares the recipe for the infamous Beefy-9 media - optimizing the classic B8 media, but for beef production.
- Want to know how to make growth factors cheaper? Find out here!
- Turns out that tailoring media to the cell type can decrease the cost and waste of growing cultured meat.
Corresponding Citations
- Krieger, J., Park, B.-W., Lambert, C. R., & Malcuit, C. (2018). 3D skeletal muscle fascicle engineering is improved with TGF-β1 treatment of myogenic cells and their co-culture with myofibroblasts. PeerJ, 6, e4939.
- Simsa, R., Yuen, J., Stout, A., Rubio, N., Fogelstrand, P., & Kaplan, D. L. (2019). Extracellular Heme Proteins Influence Bovine Myosatellite Cell Proliferation and the Color of Cell-Based Meat. Foods (Basel, Switzerland), 8(10).
- O’Neill, E. N., Cosenza, Z. A., Baar, K., & Block, D. E. (2020). Considerations for the development of cost-effective cell culture media for cultivated meat production. Comprehensive Reviews in Food Science and Food Safety, 20(1), 686-709.
- Cosenza, Z., & Block, D. E. (2020). A generalizable hybrid search framework for optimizing expensive design problems using surrogate models. Engineering Optimization, 1-14.
- Cosenza, Z., Block, D. E., & Baar, K. (2021). Optimization of muscle cell culture media using nonlinear design of experiments. Biotechnology Journal, 16(11), 2100228.
- Cosenza, Z., Astudillo, R., Frazier, P. I., Baar, K., & Block, D. E. (2022). Multi-information source Bayesian optimization of culture media for cellular agriculture. Biotechnology and Bioengineering.
- Stout, A. J., Mirliani, A. B., Rittenberg, M. L., Shub, M., White, E. C., Yuen, J. S. K., & Kaplan, D. L. (2022). Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat. Communications Biology, 5(1), 466.
- Venkatesan, M., Semper, C., Skrivergaard, S., Di Leo, R., Mesa, N., Rasmussen, M. K., Young, J. F., Therkildsen, M., Stogios, P. J., & Savchenko, A. (2022). Recombinant production of growth factors for application in cell culture. iScience, 25(10), 105054.
- O’Neill, E. N., Ansel, J. C., Kwong, G. A., Plastino, M. E., Nelson, J., Baar, K., & Block, D. E. (2022). Spent media analysis suggests cultivated meat media will require species and cell type optimization. npj Science of Food, 6(1), 46.
|
|
|